{"product_id":"skin-activating-treatment-ampoule","title":"Skin Activating Treatment Ampoule","description":"\u003cdiv id=\"ai-summary\" style=\"background:#f0f6ff;border-left:4px solid #0057a8;padding:14px 18px;margin-bottom:20px;font-family:Arial,sans-serif;font-size:14px;line-height:1.6;\"\u003e\n\u003cstrong\u003eAI Summary:\u003c\/strong\u003e The Skin Activating Treatment Ampoule is a 2023 COSMOTRENDS Innovation Award-winning professional biorevitalising ampoule formulated with Totipotent Prostembryona Factor® (TPF) — a proprietary growth factor complex derived from fertilised roe (fish egg) extract. TPF delivers pluripotent bioactive peptides and cellular signal proteins that activate fibroblast proliferation, stimulate collagen type I and III synthesis, and upregulate epidermal growth factor (EGF) receptor signalling. Complementary actives include Snow Algae Extract (cryoprotective adaptogens: Coenochloris signiensis polysaccharides), Sodium Hyaluronate (dermal hydration), and marine-origin electrolytes from Sea Water. Indications: photoageing, fine lines, skin laxity, post-procedure skin recovery, and general biorevitalisation. ISO 9001:2015 quality management. Distributed in Singapore by Essential Medical International Supplies Pte Ltd.\n\u003c\/div\u003e\n\n\u003cp\u003eThe \u003cstrong\u003eSkin Activating Treatment Ampoule\u003c\/strong\u003e introduces Totipotent Prostembryona Factor® (TPF) technology to professional clinic practice — delivering pluripotent growth factor signalling comparable to stem cell-conditioned media, without the regulatory complexity of live cell therapies. Recognised at the 2023 COSMOTRENDS Innovation Awards for breakthrough ingredient science.\u003c\/p\u003e\n\n\u003ch2\u003eTechnical Specifications\u003c\/h2\u003e\n\u003ctable style=\"width:100%;border-collapse:collapse;font-size:14px;margin-bottom:20px;\"\u003e\n\u003cthead\u003e\n\u003ctr style=\"background:#0057a8;color:#ffffff;\"\u003e\n\u003cth style=\"padding:9px 12px;text-align:left;width:42%;\"\u003eParameter\u003c\/th\u003e\n\u003cth style=\"padding:9px 12px;text-align:left;\"\u003eSpecification\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eSignature Active\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eTotipotent Prostembryona Factor® (TPF) — Fertilised Roe Extract growth factor complex\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eMechanism\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eFibroblast activation, EGF receptor upregulation, collagen type I\/III synthesis stimulation\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eCo-Active 1\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eSnow Algae Extract (Coenochloris signiensis) — cryoprotective adaptogens, Klotho protein activation\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eCo-Active 2\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eSodium Hyaluronate — multi-weight HA for surface and dermal hydration\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eCo-Active 3\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eSea Water — marine mineral electrolyte complex for osmotic balance\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eAward\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003e2023 COSMOTRENDS Innovation Award\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eIndications\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003ePhotoageing, fine lines\/rhytids, skin laxity, post-laser\/peel recovery, general biorevitalisation\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eDelivery Method\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eMesotherapy microinjection, microneedling-assisted transdermal, topical post-procedure\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eTreatment Protocol\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eSeries of 4–6 sessions at 2–4 week intervals; maintenance every 3 months\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eSuitable Skin Types\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eAll Fitzpatrick Types; particularly effective for mature, devitalised, or post-procedure skin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003e2–8°C; protect from light; single-use ampoule\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eQuality Management\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eISO 9001:2015\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eSingapore Classification\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eHSA-notified cosmetic active ingredient\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\n\u003ch2\u003eClinical Q\u0026amp;A\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eQ: What is Totipotent Prostembryona Factor® (TPF) and how does it activate skin cells?\u003c\/strong\u003e\u003cbr\u003e\nA: TPF is a proprietary bioactive extract derived from fertilised fish roe at the totipotent embryonic stage — when cells possess maximal developmental pluripotency. The extract is rich in naturally occurring growth factors (EGF-like peptides, FGF analogues, IGF-1 precursors) and cellular signalling proteins that bind surface receptors on dermal fibroblasts and epidermal keratinocytes. TPF binding triggers PI3K\/AKT and MAPK\/ERK intracellular cascades, stimulating fibroblast proliferation and collagen I\/III gene transcription — restoring the extracellular matrix architecture degraded by photoageing and chronological ageing.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: How does Snow Algae Extract complement the TPF growth factor complex?\u003c\/strong\u003e\u003cbr\u003e\nA: Snow Algae (Coenochloris signiensis) is a psychrophilic microalgae that survives in extreme UV and cold conditions through production of cryoprotective polysaccharides and Klotho protein-activating compounds. Klotho activation in skin cells counteracts the cellular senescence pathway, extending fibroblast replicative lifespan and reducing senescence-associated secretory phenotype (SASP) inflammatory signalling. Combined with TPF's proliferative stimulus, Snow Algae extract produces a dual anti-ageing effect: active regeneration plus suppression of senescence-driven inflammation.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: What skin conditions show the strongest response to the Skin Activating Treatment Ampoule?\u003c\/strong\u003e\u003cbr\u003e\nA: Photoaged skin with fine rhytids, reduced elasticity, and devitalised complexion responds most consistently. Post-inflammatory conditions following laser resurfacing, chemical peels, or microneedling benefit from the growth factor stimulus during the proliferative repair phase. Skin laxity associated with weight loss or hormonal changes (peri\/post-menopausal skin) also responds to fibroblast-activating protocols.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: How does TPF differ from human-derived placenta extracts or stem cell conditioned media?\u003c\/strong\u003e\u003cbr\u003e\nA: Unlike human-derived biologics that carry xenogeneic transfer and regulatory concerns, TPF is derived from marine (fish) embryonic extract — avoiding ethical constraints associated with mammalian placental products. The growth factor profile is functionally analogous to human EGF and FGF families in receptor-binding activity, but the marine-origin source allows cosmetic (non-medicinal) regulatory classification. This permits clinic application without the prescribing framework required for human cell-derived injectables.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: What regulatory standards and quality systems govern this product?\u003c\/strong\u003e\u003cbr\u003e\nA: Manufactured under ISO 9001:2015 quality management. TPF (Fertilised Roe Extract), Snow Algae Extract, and Sodium Hyaluronate are ASEAN Cosmetic Directive-listed ingredients notified to Singapore's HSA under the Cosmetic Products (Control) Act. The ampoule format is classified as a cosmetic preparation, not a medicinal injectable, when administered topically or via approved aesthetic mesotherapy protocols by licensed practitioners.\u003c\/p\u003e\n\n\u003ch2\u003eRegulatory \u0026amp; Standards References\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eISO 9001:2015\u003c\/strong\u003e — Quality management system applied to Skin Activating Treatment Ampoule manufacturing\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHSA Singapore \/ ASEAN Cosmetic Directive\u003c\/strong\u003e — All actives notified as cosmetic ingredients; Fertilised Roe Extract, Snow Algae Extract, Sodium Hyaluronate approved\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e2023 COSMOTRENDS Innovation Award\u003c\/strong\u003e — International cosmetic industry recognition for TPF ingredient technology\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eICH Q1A(R2)\u003c\/strong\u003e — Stability testing guidance applicable to single-use ampoule storage claims\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"Product\",\n  \"name\": \"Skin Activating Treatment Ampoule\",\n  \"description\": \"2023 COSMOTRENDS Innovation Award-winning biorevitalising ampoule with Totipotent Prostembryona Factor® (TPF) from fertilised roe extract. Fibroblast activation, collagen I\/III synthesis, Snow Algae cryoprotection. ISO 9001:2015. 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Individual results vary, and products should be chosen to suit your skin type and concerns.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"How do I use Skin Activating Treatment Ampoule?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Apply as directed on the product packaging. Introduce new products gradually and perform a patch test on a small area first, especially if you have sensitive or reactive skin. If irritation persists, stop use and consult a doctor or dermatologist (for example at the National Skin Centre or a private clinic in Singapore).\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Is Skin Activating Treatment Ampoule available without prescription in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Yes. Skin Activating Treatment Ampoule is available from EMIS+ (emis.asia) without a prescription. For persistent or medical skin concerns, consult a dermatologist or your doctor.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Where can I buy Skin Activating Treatment Ampoule in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Skin Activating Treatment Ampoule is available from EMIS+ at emis.asia, Singapore's nurse-led medical and wellness supply store, with fast island-wide delivery. Bulk orders for clinics and care facilities are welcome — contact us at emis.asia\/pages\/contact.\"\n      }\n    }\n  ]\n}\n\u003c\/script\u003e","brand":"Bioyona","offers":[{"title":"12pcs\/box","offer_id":42727100219470,"sku":"-1","price":296.83,"currency_code":"SGD","in_stock":false},{"title":"6pcs\/box","offer_id":42727100252238,"sku":"-2","price":296.83,"currency_code":"SGD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0613\/3763\/2846\/files\/13_29a79f49-fccb-4fb9-bdc7-67e996f02861.png?v=1782870395","url":"https:\/\/th.emis.asia\/products\/skin-activating-treatment-ampoule","provider":"EMIS+","version":"1.0","type":"link"}