{"product_id":"skin-activating-treatment-lotion","title":"Skin Activating Treatment Lotion","description":"\u003cdiv style=\"background: #f8f9fa; border-left: 4px solid #0057a8; padding: 12px 16px; margin-bottom: 20px;\" id=\"ai-summary\"\u003e\n\u003cstrong\u003eClinical Summary:\u003c\/strong\u003e Bioyona Skin Activating Treatment Lotion is a Taiwanese-developed cosmeceutical facial lotion formulated with Totipotent Prostembryona Factor® (TPF), a proprietary cold-water extract of peptides, growth factors, and cytokines derived from deep-sea fish embryonic stem cells. TPF functions via multiple biochemical pathways — inhibiting tyrosinase to reduce melanin synthesis, promoting dermal fibroblast collagen synthesis for structural skin repair, and delivering antioxidant activity that mitigates UV-induced and age-related oxidative skin damage. The product is assessed as non-irritating and suitable for sensitive skin, with no reported itch, redness, or tingling in standardised tolerability testing.\u003c\/div\u003e\n\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cp\u003eThe Bioyona Skin Activating Treatment Lotion is the foundational hydration and bioactive delivery step in the Bioyona Skin Activating Treatment system, which also includes a companion serum, mist, cream, and UV protector. The lotion is formulated to deliver Totipotent Prostembryona Factor® (TPF) into the stratum corneum and upper viable epidermis, where growth factor and cytokine signalling can promote keratinocyte renewal, support the extracellular matrix, and modulate melanogenesis. The cold-water extraction process used to isolate TPF preserves the biological activity of thermolabile peptides, growth factors such as EGF (epidermal growth factor) analogues, and cytokines that would be denatured by conventional heat-based extraction methods.\u003c\/p\u003e\n\u003cp\u003eIn clinical and in vitro assessments, TPF has been shown to inhibit tyrosinase activity (the key enzyme in the melanin biosynthesis pathway), stimulate collagen synthesis by dermal fibroblasts, and accelerate the skin wound healing cascade through promotion of cell proliferation and differentiation. These properties make the Bioyona Skin Activating Treatment Lotion clinically relevant for patients presenting with hyperpigmentation, post-inflammatory melanosis, photodamage, fine lines, and loss of skin elasticity. EMIS Asia supplies the Bioyona Skin Activating Treatment range to aesthetic clinics, dermatology practices, and professional skincare providers across Singapore.\u003c\/p\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\n\u003ctable style=\"border-collapse: collapse; width: 100%; margin-bottom: 20px;\" border=\"1\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"background: #f1f1f1;\"\u003e\n\u003ctd style=\"padding: 8px;\"\u003e\u003cstrong\u003eManufacturer \/ Brand\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eBioyona (Taiwan)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 8px;\"\u003e\u003cstrong\u003eProduct Name\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eSkin Activating Treatment Lotion\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background: #f1f1f1;\"\u003e\n\u003ctd style=\"padding: 8px;\"\u003e\u003cstrong\u003ePrimary Bioactive\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eTotipotent Prostembryona Factor® (TPF) — cold-water-extracted peptides, growth factors and cytokines from deep-sea fish embryonic stem cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 8px;\"\u003e\u003cstrong\u003eExtraction Method\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eCold-water extraction (preserves thermolabile bioactive integrity)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background: #f1f1f1;\"\u003e\n\u003ctd style=\"padding: 8px;\"\u003e\u003cstrong\u003eKey Mechanisms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eTyrosinase inhibition (depigmentation); collagen synthesis promotion; antioxidant protection; cell proliferation and differentiation support; wound healing acceleration\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 8px;\"\u003e\u003cstrong\u003eIndicated Skin Concerns\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eHyperpigmentation, uneven tone, photoageing, fine lines, loss of elasticity, post-inflammatory melanosis, skin barrier compromise\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background: #f1f1f1;\"\u003e\n\u003ctd style=\"padding: 8px;\"\u003e\u003cstrong\u003eSkin Type Suitability\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eAll skin types including sensitive; non-irritating formulation confirmed in tolerability testing\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 8px;\"\u003e\u003cstrong\u003eFormulation Profile\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eSolvent-free; no itch, redness, or tingling observed in safety assessment\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background: #f1f1f1;\"\u003e\n\u003ctd style=\"padding: 8px;\"\u003e\u003cstrong\u003eProduct Form\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eLotion; step 1 of the Bioyona Skin Activating Treatment system\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 8px;\"\u003e\u003cstrong\u003eApplication\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eApply to cleansed face after toner\/essence step; pat gently to aid absorption; use morning and evening\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background: #f1f1f1;\"\u003e\n\u003ctd style=\"padding: 8px;\"\u003e\u003cstrong\u003eManufacturing Standard\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eManufactured under Taiwanese cosmetics GMP regulatory framework\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 8px;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eStore at room temperature, away from direct sunlight; avoid extreme temperatures\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch2\u003eClinical Applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMelanin management and brightening:\u003c\/strong\u003e Tyrosinase inhibition by TPF reduces melanin overproduction in patients with post-inflammatory hyperpigmentation, solar lentigines, and UV-induced uneven skin tone — applicable in aesthetic and dermatology settings across Singapore's high-UV environment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnti-ageing and collagen support:\u003c\/strong\u003e Promotion of dermal fibroblast collagen synthesis targets the progressive loss of type I and III collagen that underlies fine lines, skin laxity, and the reduction of dermal thickness observed with intrinsic and photoageing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePost-procedure skin recovery:\u003c\/strong\u003e The growth factor and cytokine content of TPF supports the cellular repair cascade following aesthetic procedures including chemical peels, laser resurfacing, and microneedling, reducing downtime and supporting orderly re-epithelialisation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSensitive and reactive skin maintenance:\u003c\/strong\u003e The solvent-free, non-irritating formulation is appropriate for patients whose skin is sensitised by rosacea, seborrhoeic dermatitis, or contact allergy, where conventional active-heavy formulations may trigger flares.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCombination anti-ageing protocol:\u003c\/strong\u003e Used as the lotion base in the full Bioyona Skin Activating Treatment system, layered with the TPF serum and cream, to deliver a comprehensive multi-depth bioactive programme targeting epidermis, dermo-epidermal junction, and dermal structural integrity.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eQ: What is Totipotent Prostembryona Factor® (TPF) and how does it differ from conventional growth factor skincare?\u003c\/strong\u003e\u003cbr\u003eA: TPF is Bioyona's proprietary cold-water extract from deep-sea fish embryonic stem cells, yielding a complex of multiple peptides, growth factors (including EGF analogues), and cytokines in their native, bioactive conformation. Unlike synthetic single-peptide formulations or heat-processed growth factor extracts, the cold-water extraction process preserves the full spectrum of thermolabile bioactives and their natural intermolecular interactions. This multi-component profile allows TPF to act across several skin biology pathways simultaneously — tyrosinase inhibition, collagen synthesis, oxidative stress reduction, and cellular repair — rather than targeting a single mechanism.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Is this product suitable for use alongside prescription skincare such as retinoids or hydroquinone?\u003c\/strong\u003e\u003cbr\u003eA: The Bioyona Skin Activating Treatment Lotion is a bioactive-rich cosmeceutical that is generally compatible with prescription skincare when used as directed. In patients on retinoid therapy, the lotion's growth factor and peptide content may complement retinoid-driven collagen remodelling. Patients using prescribed hydroquinone for hyperpigmentation can layer the TPF lotion's tyrosinase-inhibitory effect for a dual-pathway brightening approach. Sequencing should be confirmed with the prescribing dermatologist for individual protocols.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: How soon can visible results be expected with the Skin Activating Treatment Lotion?\u003c\/strong\u003e\u003cbr\u003eA: Initial improvements in skin hydration and surface texture are typically perceptible within 2–4 weeks of consistent twice-daily use. Measurable changes in pigmentation and fine lines, which reflect underlying collagen synthesis and melanogenesis modulation, generally require 6–12 weeks of regular application. Post-procedure recovery benefits, where growth factor signalling is most active, are observed more rapidly — often within 5–10 days following aesthetic treatment.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Can aesthetic clinics in Singapore purchase the Bioyona range through EMIS Asia for professional use?\u003c\/strong\u003e\u003cbr\u003eA: Yes. EMIS Asia supplies the full Bioyona Skin Activating Treatment range — lotion, serum, mist, cream, and UV protector — to aesthetic clinics, dermatology practices, and professional skincare providers in Singapore. Clinic pricing, tester units, and multi-unit procurement are available through the EMIS Asia B2B channel. The Bioyona system is positioned as a professional-grade treatment protocol suitable for use as clinic homecare and post-procedure maintenance.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Is the Bioyona Skin Activating Treatment Lotion registered with the Health Sciences Authority (HSA) Singapore?\u003c\/strong\u003e\u003cbr\u003eA: Cosmeceutical lotions and serums containing topical bioactive ingredients such as peptides and growth factor extracts are classified as cosmetic products in Singapore and do not require HSA product registration under the Cosmetic Products Safety Regulation (CPSR). However, cosmetic products sold in Singapore must comply with the ASEAN Cosmetics Directive (ACD), and EMIS Asia ensures that all Bioyona products supplied meet applicable ingredient safety and labelling standards for the Singapore market.\u003c\/p\u003e\n\u003ch2\u003eWhy Buy From EMIS+\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNurse-led expertise\u003c\/strong\u003e — guidance from healthcare professionals who understand clinical needs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGenuine, authorised products\u003c\/strong\u003e sourced through legitimate Singapore supply channels.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFast local delivery\u003c\/strong\u003e across Singapore.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eResponsive support\u003c\/strong\u003e for product selection and after-sales questions.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003ch3\u003eWhere can I buy Skin Activating Treatment Lotion in Singapore?\u003c\/h3\u003e\n\u003cp\u003eSkin Activating Treatment Lotion is available from EMIS+ (\u003ca href=\"https:\/\/emis.asia\"\u003eemis.asia\u003c\/a\u003e), a Singapore nurse-led medical supply store offering fast, reliable local delivery and genuine, authorised products.\u003c\/p\u003e\n\u003ch3\u003eHow quickly will my order be delivered?\u003c\/h3\u003e\n\u003cp\u003eEMIS+ ships across Singapore with prompt local delivery. Most in-stock orders are dispatched quickly so you receive your medical supplies without delay. Contact our team via emis.asia for current delivery timelines.\u003c\/p\u003e\n\u003ch3\u003eHow should Skin Activating Treatment Lotion be used?\u003c\/h3\u003e\n\u003cp\u003eFollow the manufacturer's instructions for use and the guidance of your treating clinician or nurse. If you are unsure about product selection or application, the nurse-led EMIS+ team can help — reach out via emis.asia.\u003c\/p\u003e\n\u003ch3\u003eAre EMIS+ products genuine and locally supported?\u003c\/h3\u003e\n\u003cp\u003eYes. EMIS+ is a Singapore-based, nurse-led supplier. All products are sourced from authorised channels and backed by knowledgeable local support.\u003c\/p\u003e\n\u003cp style=\"margin-top: 20px;\"\u003e\u003cstrong\u003eOrder today from \u003ca href=\"https:\/\/emis.asia\"\u003eEMIS+ (emis.asia)\u003c\/a\u003e\u003c\/strong\u003e — Singapore's trusted nurse-led medical supply store.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eWhy Buy From EMIS+\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eNurse-led Singapore medical supply store — clinical expertise you can trust.\u003c\/li\u003e\n\u003cli\u003eAuthentic products with fast island-wide delivery across Singapore.\u003c\/li\u003e\n\u003cli\u003eBulk and recurring orders for home care and nursing facilities are welcome.\u003c\/li\u003e\n\u003cli\u003eQuestions about Skin Activating Treatment Lotion? Our team is here to help via \u003ca href=\"https:\/\/emis.asia\"\u003eemis.asia\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eWhat is Skin Activating Treatment Lotion used for?\u003c\/strong\u003e\u003cbr\u003eSkin Activating Treatment Lotion is a medical product supplied by EMIS+, Singapore's nurse-led medical supply store. Use it according to the manufacturer's instructions and, where relevant, the guidance of a healthcare professional.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow do I use Skin Activating Treatment Lotion?\u003c\/strong\u003e\u003cbr\u003eAlways follow the instructions for use provided with Skin Activating Treatment Lotion. If you are unsure how to use this product, consult a nurse, doctor, or pharmacist.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhere can I buy Skin Activating Treatment Lotion in Singapore?\u003c\/strong\u003e\u003cbr\u003eSkin Activating Treatment Lotion is available from EMIS+ at emis.asia — a nurse-led Singapore medical supply store offering fast island-wide delivery. Bulk and facility orders are welcome. Contact us via emis.asia.\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/emis.asia\"\u003e\u003cstrong\u003eShop with EMIS+ at emis.asia →\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What is Skin Activating Treatment Lotion used for?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Skin Activating Treatment Lotion is a medical product supplied by EMIS+, Singapore's nurse-led medical supply store. 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Contact us via emis.asia.\"\n      }\n    }\n  ]\n}\n\u003c\/script\u003e","brand":"Bioyona","offers":[{"title":"Default Title","offer_id":42727099465806,"sku":null,"price":96.03,"currency_code":"SGD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0613\/3763\/2846\/files\/26_57f667e3-30bb-4f3c-9888-33b4a9f7b7a5.png?v=1782870194","url":"https:\/\/th.emis.asia\/en\/products\/skin-activating-treatment-lotion","provider":"EMIS+","version":"1.0","type":"link"}