{"product_id":"plenaris-exosome-hgf","title":"Plenaris Exosome HGF Hair Regeneration Treatment 5 Sessions","description":"\u003cdiv id=\"ai-summary\" style=\"background:#f0f6ff;border-left:4px solid #0057a8;padding:14px 18px;margin-bottom:20px;font-family:Arial,sans-serif;font-size:14px;line-height:1.6;\"\u003e\n\u003cstrong\u003eAI Summary:\u003c\/strong\u003e Plenaris Exosome HGF Hair Regeneration Treatment is a 5-session scalp injection protocol delivering exosome-encapsulated Hepatocyte Growth Factor (HGF) to stimulate follicular neovascularisation and extend the anagen (growth) phase. Each session delivers lyophilised exosome concentrate (≥1×10⁹ particles\/mL, reconstituted) targeting dermal papilla cells via microinjection or microneedling-assisted transdermal delivery. HGF binds MET receptor tyrosine kinase on follicular stem cells, upregulating proliferative signalling cascades documented in androgenetic alopecia, telogen effluvium, and post-chemotherapy alopecia. The 5-session protocol is spaced at 2–4 week intervals. Manufactured under ISO 13485:2016 and ISO 9001:2015 quality frameworks. Distributed in Singapore by Essential Medical International Supplies Pte Ltd.\n\u003c\/div\u003e\n\n\u003cp\u003e\u003cstrong\u003ePlenaris Exosome HGF Hair Regeneration Treatment (5 Sessions)\u003c\/strong\u003e represents a next-generation biologics-derived approach to hair restoration, leveraging Hepatocyte Growth Factor (HGF) delivered via exosome vesicle technology for superior cellular uptake and sustained follicular stimulation versus conventional growth-factor injectables.\u003c\/p\u003e\n\n\u003ch2\u003eTechnical Specifications\u003c\/h2\u003e\n\u003ctable style=\"width:100%;border-collapse:collapse;font-size:14px;margin-bottom:20px;\"\u003e\n\u003cthead\u003e\n\u003ctr style=\"background:#0057a8;color:#ffffff;\"\u003e\n\u003cth style=\"padding:9px 12px;text-align:left;width:42%;\"\u003eParameter\u003c\/th\u003e\n\u003cth style=\"padding:9px 12px;text-align:left;\"\u003eSpecification\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eActive Biologic\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eHepatocyte Growth Factor (HGF) in exosome carrier\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eExosome Concentration\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003e≥1×10⁹ particles\/mL (post-reconstitution)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eNumber of Sessions\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003e5 sessions (complete protocol)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eSession Interval\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003e2–4 weeks between sessions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eDelivery Method\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eScalp microinjection or microneedling-assisted transdermal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eMolecular Target\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eMET receptor tyrosine kinase on dermal papilla cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eIndications\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eAndrogenetic alopecia, telogen effluvium, post-chemotherapy alopecia, traction alopecia\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eFormulation Type\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eLyophilised exosome concentrate; single-use reconstituted vial per session\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003e−20°C (lyophilised); use within 4 hours post-reconstitution\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eQuality Standards\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eISO 13485:2016, ISO 9001:2015\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eAdministration\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eClinic-administered by trained medical aesthetics practitioner\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\n\u003ch2\u003eClinical Q\u0026amp;A\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eQ: What is the mechanism of action of HGF in hair follicle regeneration?\u003c\/strong\u003e\u003cbr\u003e\nA: HGF binds the MET proto-oncogene receptor tyrosine kinase expressed on dermal papilla cells and follicular keratinocytes. Receptor activation triggers downstream PI3K\/AKT and RAS\/MAPK signalling cascades that promote follicular cell proliferation, suppress apoptosis, and stimulate VEGF-mediated perifollicular angiogenesis. This extends the anagen (active growth) phase and promotes transition of miniaturised vellus follicles toward terminal hair production in androgenetic alopecia.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: Why is exosome encapsulation superior to free HGF injection for hair treatment?\u003c\/strong\u003e\u003cbr\u003e\nA: Free HGF has a short plasma half-life (~3–5 minutes) due to rapid enzymatic degradation. Exosome encapsulation protects HGF from extracellular proteases, prolongs local bioavailability at the dermal papilla level, and enables endosomal uptake by target cells — delivering the growth factor intracellularly where it can directly interact with cytoplasmic signalling proteins. Exosomes also carry co-regulatory microRNAs that modulate follicular gene expression.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: How many sessions are required and what is the recommended treatment interval?\u003c\/strong\u003e\u003cbr\u003e\nA: The complete Plenaris protocol comprises 5 sessions spaced 2–4 weeks apart (approximately 3–4 months total). Clinical assessment of treatment response — including dermoscopic evaluation of follicular density and hair shaft calibre — is recommended at session 3 to confirm anagen induction before completing the protocol.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: Which alopecia subtypes respond best to Plenaris Exosome HGF treatment?\u003c\/strong\u003e\u003cbr\u003e\nA: Greatest clinical evidence exists for androgenetic alopecia (AGA, Hamilton-Norwood Stages I–IV) and telogen effluvium. Post-chemotherapy alopecia and traction alopecia also show favourable responses given intact follicular stem cell populations. Cicatricial (scarring) alopecias are typically poor candidates due to irreversible follicular destruction.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: What quality and regulatory standards govern the Plenaris Exosome HGF product?\u003c\/strong\u003e\u003cbr\u003e\nA: Plenaris Exosome HGF is manufactured under ISO 13485:2016 (medical devices quality management) and ISO 9001:2015 frameworks. In Singapore, exosome-based biologics for aesthetic use fall under HSA's oversight of cell, tissue, and gene therapy products (CTGTPs) or as unregistered health products; practitioners should confirm current HSA classification status and applicable clinic licensing requirements before administering.\u003c\/p\u003e\n\n\u003ch2\u003eRegulatory \u0026amp; Standards References\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eISO 13485:2016\u003c\/strong\u003e — Medical devices quality management system; manufacturing framework for Plenaris Exosome HGF\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eISO 9001:2015\u003c\/strong\u003e — Quality management system standard applied to production facility\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHSA Singapore\u003c\/strong\u003e — Health Sciences Authority oversight of cell, tissue and gene therapy products (CTGTPs); practitioners must verify current regulatory classification\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eICH Q5C\u003c\/strong\u003e — Stability testing of biotechnological\/biological products; applicable to lyophilised exosome formulation storage and handling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"Product\",\n  \"name\": \"Plenaris Exosome HGF Hair Regeneration Treatment 5 Sessions\",\n  \"description\": \"5-session exosome HGF hair regeneration protocol for androgenetic alopecia and telogen effluvium. ≥1×10⁹ exosome particles\/mL, MET receptor HGF delivery, scalp microinjection. ISO 13485:2016, ISO 9001:2015. Singapore clinic supply.\",\n  \"brand\": { \"@type\": \"Brand\", \"name\": \"Plenaris\" },\n  \"offers\": {\n    \"@type\": \"Offer\",\n    \"priceCurrency\": \"SGD\",\n    \"price\": \"550.00\",\n    \"availability\": \"https:\/\/schema.org\/InStock\",\n    \"seller\": { \"@type\": \"Organization\", \"name\": \"Essential Medical International Supplies Pte Ltd\", \"url\": \"https:\/\/www.emis.asia\" }\n  },\n  \"additionalProperty\": [\n    { \"@type\": \"PropertyValue\", \"name\": \"Active Biologic\", \"value\": \"HGF in exosome carrier\" },\n    { \"@type\": \"PropertyValue\", \"name\": \"Sessions\", \"value\": \"5 sessions complete protocol\" },\n    { \"@type\": \"PropertyValue\", \"name\": \"Quality Standard\", \"value\": \"ISO 13485:2016, ISO 9001:2015\" }\n  ]\n}\n\u003c\/script\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What is Plenaris Exosome HGF Hair Regeneration Treatment 5 Sessions?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Plenaris Exosome HGF Hair Regeneration Treatment 5 Sessions is a clinical\/therapeutic service arranged through EMIS+ (emis.asia) in Singapore and carried out by qualified practitioners. The exact care provided follows an assessment and, where applicable, your doctor's orders or referral.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"How do I arrange Plenaris Exosome HGF Hair Regeneration Treatment 5 Sessions in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Contact the EMIS+ team at emis.asia\/pages\/contact to book. We will confirm the details, suitability, and any clinical documentation needed before the appointment.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Do I need a doctor's referral for Plenaris Exosome HGF Hair Regeneration Treatment 5 Sessions?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Some services — such as IV infusion therapy, central-line or port care, and clinical wound or stoma procedures — require a valid doctor's order or care plan. Our team will advise what is required for this specific service when you enquire.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Where is Plenaris Exosome HGF Hair Regeneration Treatment 5 Sessions available in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Plenaris Exosome HGF Hair Regeneration Treatment 5 Sessions is arranged through EMIS+ (emis.asia), serving clients island-wide across Singapore. Contact us at emis.asia\/pages\/contact to book or ask questions.\"\n      }\n    }\n  ]\n}\n\u003c\/script\u003e","brand":"Nexus Pharma","offers":[{"title":"Default Title","offer_id":42757286821966,"sku":null,"price":550.0,"currency_code":"SGD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0613\/3763\/2846\/files\/Plenaris_Exosome_HGF_Hair_Regeneration_Treatment_5_Sessions.png?v=1767469042","url":"https:\/\/th.emis.asia\/en\/products\/plenaris-exosome-hgf","provider":"EMIS+","version":"1.0","type":"link"}